Raf family

Definition:

Raf family are conserved, ubiquitous serine/protein kinases. The Raf protein kinases are key intermediates in cellular signal transduction, functioning as direct effectors of the RAS GTPases and as the initiating kinases in the Extracellular signal-regulated kinases (ERKs) cascade. Raf family includes A-Raf, B-Raf and C-Raf, possess a Ras-binding domain (RBD) in their N-terminal regulatory region and can function as effectors of active GTP-bound RAS family

References:

[1]. G Maurer, et al. Raf kinases in cancer-roles and therapeutic opportunities. Oncogene. 2011 Aug 11;30(32):3477-88. [Content Brief]

[2]. David E Durrant, et al. Targeting the Raf kinases in human cancer: the Raf dimer dilemma. Br J Cancer. 2018 Jan;118(1):3-8. [Content Brief]

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